The symptoms associated with BPH are related to bladder outlet obstruction, which is comprised of two underlying components: a static component and a dynamic component. The static component is a consequence of an increase in prostate size. Over time, the prostate will continue to enlarge. However, clinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction. The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck, leading to constriction of the bladder outlet. Smooth muscle tone is mediated by sympathetic nervous stimulation of alpha-1 adrenoceptors, which are abundant in the prostate, prostatic capsule and bladder neck. The reduction in symptoms and improvement in urine flow rates following administration of Terazosin is related to relaxation of smooth muscle produced by blockade of alpha-1 adrenoceptors in the bladder neck and prostate. Because there are relatively few alpha-1 adrenoceptors in the bladder body, Terazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility.
Store in the refrigerator between 36-46 degrees F 2-8 degrees C. When traveling, this product may remain at room temperature at 72 degrees F 22 degrees C away from light and moisture for up to 3 weeks. Discard after 3 weeks out of the refrigerator. Keep the bottle upright. Do not store in the bathroom. Keep all medicines away from children and pets. Terazosin capsules, USP, for oral administration, are supplied in four dosage strengths containing Terazosin hydrochloride, USP equivalent to 1 mg, 2 mg, 5 mg, or 10 mg of Terazosin. Inactive ingredients: Crospovidone, lactose monohydrate magnesium stearate, and microcrystalline cellulose. May contain corn starch.
Additional adverse reactions have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose. Terazosin capsules. You must take it every day at the dose prescribed. Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly.
Remember that terazosin will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. Roberts RG. Novel idea in BPH guideline: the patient as decision maker. Am Fam Physician. Ketamine: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. Tell your doctor if your condition does not improve or if this medication stops working well.
Some medical conditions may interact with terazosin. National Heart, Lung, and Blood Institute. New analysis regarding the safety of calcium-channel blockers: a statement for health professionals from the National Heart, Lung, and Blood Institute. Monda JM, Oesterling JE. Medical treatment of benign prostatic hyperplasia: 5α-reductase inhibitors and α- adrenergic antagonists. Mayo Clin Proc. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. Suppositories. Manufactured for: Janssen Pharmaceuticals, Inc. Terazosin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Chlorpheniramine; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Diazoxide: Additive hypotensive effects can occur with the concomitant administration of diazoxide with other antihypertensive agents. This interaction can be therapeutically advantageous, but dosages must be adjusted accordingly. The manufacturer advises that IV diazoxide should not be administered to patients within 6 hours of receiving other antihypertensive agents. Patients should also be told that drowsiness or somnolence can occur with terazosin, requiring caution in people who must drive or operate heavy machinery. Niacin; Simvastatin: Cutaneous vasodilation induced by niacin may become problematic if high-dose niacin is used concomitantly with other antihypertensive agents. This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. Guaifenesin; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Eletriptan: Eletriptan may cause increased blood pressure and reduce the effectiveness of antihypertensive agents, such as alpha-blockers. Patients on antihypertensives need to have their blood pressure adequately controlled if they are to receive eletriptan. If eletriptan is used, regular blood pressure monitoring is recommended.
Torsade de Pointes is the only arrhythmia that showed a dose-response relationship to Tikosyn treatment. It did not occur in placebo treated patients. BID; doses greater than 500 mcg BID have been associated with an increased incidence of Torsade de Pointes. Patients should also be told that drowsiness or somnolence can occur with Terazosin capsules, requiring caution in people who must drive or operate heavy machinery. Garraway WM, Collins GN, Lee RJ. High prevalence of benign prostatic hypertrophy in the community. Lancet. Hytrin terazosin hydrochloride is an alpha-adrenergic blocker used to treat and enlarged . Hytrin is available in form. glimepiride
Please refer patient to the Medication Guide. Tizanidine: Concurrent use of tizanidine with antihypertensive agents can result in significant hypotension. Caution is advised when tizanidine is to be used in patients receiving concurrent antihypertensive therapy. This drug is not recommended for use in children less than 2 years of age due to an increased risk of serious side effects such as very slowed breathing. Ask the doctor or for details. This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. You should avoid driving or hazardous tasks for 12 hours after the first dose, after your dose is increased, and when this medication is restarted after it has been stopped. Limit alcoholic beverages. This medicine may be harmful if swallowed. Whelton PK, Appel LJ, Espeland MA et al. for the TONE Collaborative Research Group. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly TONE. JAMA. Have your checked regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor. Your doctor will do tests before you start and while you take Tikosyn. Desmopressin can rarely cause a low level of sodium in the blood, which can be serious and possibly life-threatening. Drinking too much water or other fluids increases the risk of having a low level of sodium in the blood. Therefore, follow your doctor's directions for limiting fluids. Carbinoxamine; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Black HR, Elliott WJ, Neaton JD et al. Baseline characteristics and elderly blood pressure control in the CONVINCE trial. Hypertension. About Prostate Specific Antigen PSA. Your doctor may have done a blood test called PSA. Your doctor is aware that terazosin hydrochloride does not affect PSA levels. You may want to ask your doctor more about this if you have had a PSA test done. Not known whether terazosin is distributed into milk. 1 Caution if used in nursing women. If any of these effects persist or worsen, tell your doctor or promptly. pdox.info maxalt
Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure JNC V. Arch Intern Med. There was a tendency for patients to gain weight during Terazosin therapy. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Hydralazine; Isosorbide Dinitrate, ISDN: Concomitant use of nitrates with other antihypertensive agents can cause additive hypotensive effects. Dosage adjustments may be necessary. Terazosin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Guthrie R "Terazosin in the treatment of hypertension and symptomatic benign prostatic hyperplasia - a primary care trial. Number of patients evaluated for QTc change: 478 Tikosyn, 167 placebo. Lasagna L. Diuretics vs α-blockers for treatment of hypertension: lessons from ALLHAT. JAMA. The prevalence of adverse reactions has been ascertained from clinical trials conducted primarily in the United States. All adverse experiences events reported during these trials were recorded as adverse reactions. The prevalence rates presented below are based on combined data from fourteen placebo-controlled trials involving once-a-day administration of Terazosin, as monotherapy or in combination with other antihypertensive agents, at doses ranging from 1 to 40 mg. Table 3 summarizes those adverse experiences reported for patients in these trials where the prevalence rate in the Terazosin group was at least 5%, where the prevalence rate for the Terazosin group was at least 2% and was greater than the prevalence rate for the placebo group, or where the reaction is of particular interest. Holtzman JL, Kaihlanen PM, Rider A et al. Concomitant administration of the terazosin and atenolol for the treatment of essential hypertension. Arch Intern Med. Extremely rarely, terazosin hydrochloride and similar medications have caused painful erection of the penis, sustained for hours and unrelieved by sexual intercourse or masturbation. This condition is serious, and if untreated it can be followed by permanent inability to have an erection. If you have a prolonged abnormal erection, call your doctor or go to emergency room as soon as possible. Alemtuzumab: Alemtuzumab may cause hypotension. Careful monitoring of blood pressure and hypotensive symptoms is recommended especially in patients with ischemic heart disease and in patients on antihypertensive agents. Nicotine: Nicotine use may reduce the clinical effects of the alpha-blockers. If significant changes in nicotine intake occur, the dosages of these drugs may need adjustment. Lepor H. The emerging role of alpha antagonists in the therapy of benign prostatic hyperplasia. J Androl. Using terazosin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Take terazosin by mouth with or without food.
Renal function and QTc should be re-evaluated every three months or as medically warranted. If QTc exceeds 500 milliseconds 550 msec in patients with ventricular conduction abnormalities Tikosyn therapy should be discontinued and patients should be carefully monitored until QTc returns to baseline levels. Ethinyl Estradiol: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. Rarely, probably less than once in every several thousand patients Terazosin and other α 1-antagonists have been associated with priapism painful penile erection, sustained for hours and unrelieved by sexual intercourse or masturbation. Two or three dozen cases have been reported. Limited measurements of peak response 2 to 3 hours after dosing during chronic Terazosin administration indicate that it is greater than about twice the trough 24 hour response, suggesting some attenuation of response at 24 hours, presumably due to a fall in blood Terazosin concentrations at the end of the dose interval. HernandezCano N, Herranz P, Lazaro TE, Mayor M, Casado M "Severe cutaneous reaction due to terazosin. Tell your doctor or dentist that you take terazosin before you receive any medical or dental care, emergency care, or surgery including eye surgery. Use with caution; generally, increase dosage more slowly in geriatric patients than in younger adults. Your pharmacist can provide more information about terazosin. Terazosin capsules, USP are also indicated for the treatment of hypertension. Terazosin capsules, USP can be used alone or in combination with other antihypertensive agents such as diuretics or beta-adrenergic blocking agents. Baclofen: Baclofen has been associated with hypotension. Concurrent use with baclofen and antihypertensive agents may result in additive hypotension. Dosage adjustments of the antihypertensive medication may be required. Inform your doctor if your condition worsens. Hytrin, and shortly after taking the drug during the first week of treatment. buy estreva tablets australia
Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics water pills. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. Cohen JD. Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents. Dizziness, lightheadedness, tiredness, nausea, drowsiness, blurred vision, headache, or stuffy nose may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Khoury AF, Kaplan NM. α-Blocker therapy of hypertension. JAMA. In controlled trials, terazosin has been added to diuretics, and several beta-adrenergic blockers; no unexpected interactions were observed. Terazosin has also been used in patients on a variety of concomitant therapies; while these were not formal interaction studies, no interactions were observed. The adverse reactions were usually mild or moderate in intensity but sometimes were serious enough to interrupt treatment. Apraclonidine: Alpha blockers as a class may reduce heart rate and blood pressure. While no specific drug interactions have been identified with systemic agents and apraclonidine during clinical trials, it is theoretically possible that additive blood pressure reductions could occur when apraclonidine is combined with the use of antihypertensive agents. Patients using cardiovascular drugs concomitantly with apraclonidine should have their pulse and blood pressure monitored periodically. Terazosin capsules work by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure. cheapest imitrex purchase pharmacy uk
Even though you take Terazosin capsules and they may help you, Terazosin capsules may not prevent the need for surgery in the future. Terazosin hydrochloride relaxes the tightness of a certain type of muscle in the prostate and at the opening of the bladder. What are the ingredients in Tikosyn? Dermatologic side effects of skin rash have been reported rarely. Lichenoid drug eruption has been associated with terazosin therapy. If you have a history of prostate cancer, you may need a dose adjustment or special tests to safely take terazosin. Geller J. Nonsurgical treatment of prostatic hyperplasia. Cancer. Do NOT take more than the recommended dose without checking with your doctor. Because of this effect, your doctor may have told you to take Terazosin capsules at bedtime. If you take Terazosin capsules at bedtime but need to get up from bed to go to the bathroom, get up slowly and cautiously until you are sure how the medicine affects you. It is also important to get up slowly from a chair or bed at any time until you learn how you react to Terazosin capsules. You should not drive or do any hazardous tasks until you are used to the effects of the medication. If you begin to feel dizzy, sit or lie down until you feel better. Respiratory system side effects have been limited to nasal congestion in 2% to 12% of patients.
The dizziness, lightheadedness, or fainting is more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While you are taking terazosin, be careful to limit the amount of alcohol you drink. Also, use extra care during exercise or hot weather or if you must stand for long periods of time. Older adults may be more sensitive to the side effects of this drug, especially dizziness, fainting, and low blood pressure when getting up from a sitting or lying position. These side effects can increase the risk of falling. Nitroglycerin: Concomitant use of nitrates with other antihypertensive agents can cause additive hypotensive effects. Dosage adjustments may be necessary. Read the Medication Guide before you start taking Tikosyn and each time you get a refill. This information does not take the place of talking with your doctor about your condition or treatment. Mechanism of Action: Terazosin causes peripheral vasodilation by selective, competitive inhibition of vascular postsynaptic alpha1-adrenergic receptors, thereby reducing peripheral vascular resistance and blood pressure. Unlike phenoxybenzamine and phentolamine, which are nonselective alpha-adrenergic blockers, terazosin does not interfere with the feedback mechanism for neurotransmitter release. Because it does not block presynaptic alpha2-receptors, terazosin does not cause reflex activation of norepinephrine release to produce reflex tachycardia. Also, tolerance to its antihypertensive effects does not occur. Chlorpheniramine; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Terazosin helps relieve the symptoms of BPH. It does NOT change the size of the prostate, which may continue to grow. However, a larger prostate does not necessarily cause more or worse symptoms. However, terazosin will not help shrink the prostate. The prostate may continue to grow. This may cause the symptoms to become worse over time. Therefore, even though terazosin may lessen the problems caused by enlarged prostate now, surgery still may be needed in the future. Black HR, Elliott WJ, Grandits G, et al. Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points CONVINCE trial. JAMA. Additional adverse events have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to Terazosin. The safety profile of patients treated in the long-term open-label study was similar to that observed in the controlled studies. Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Number of patients evaluated for maintenance of NSR: 503 Tikosyn, 174 placebo. imiquimod money order pharmacy canada
Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Tell your doctor if your condition does not improve or if it worsens. In cases of overdose, cardiac monitoring should be initiated. Charcoal slurry may be given soon after overdosing but has been useful only when given within 15 minutes of Tikosyn administration. Treatment of Torsade de Pointes or overdose may include administration of isoproterenol infusion, with or without cardiac pacing. Administration of intravenous magnesium sulfate may be effective in the management of Torsade de Pointes. Close medical monitoring and supervision should continue until the QT interval returns to normal levels. If you miss a dose of terazosin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. It is known as an alpha agonist. It is not known whether Terazosin is excreted in breast milk. Because many drugs are excreted in breast milk, caution should be exercised when Terazosin capsules are administered to a nursing woman. If you use more than 1 dose daily and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Nervous system side effects, such as dizziness 5% to 30% of patients and blurred vision 2% of patients may be related to hypotension. Headaches 2% to 10% asthenia 8% and somnolence 6% have occurred following long-term use. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack ALLHAT. JAMA. Izzo JL, Levy D, Black HR. Importance of systolic blood pressure in older Americans. Hypertension. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using terazosin while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use terazosin, check with your doctor. Discuss any possible risks to your baby. cyproheptadine order online payment canada
These medications have specific and limited indications based on the cause and categorization of incontinence. Patients should be assessed periodically for medication effects on urinary incontinence as well as lower urinary tract symptoms and treatment tolerability. There does not appear to be a benefit of stopping alpha-1 blocker therapy prior to cataract surgery. Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. The QT interval increases linearly with increasing Tikosyn dose see and in CLINICAL PHARMACOLOGY and Dose-Response and Concentration Response for Increase in QT Interval. Constipation, diarrhea, dry mouth, dyspepsia, flatulence, vomiting. Read the patient instruction sheet that comes with this product before you start using desmopressin and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Fospropofol: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. Guaifenesin; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Upjohn Company. Caverject alprostadil injection for intracavernosal use prescribing information. Kalamazoo, MI; 1995 Jul.
To decrease risk of excessive hypotension and syncope, initiate therapy at low dose and titrate carefully, lessen level of salt restriction, and avoid diuretics just prior to initiation of terazosin therapy. Food has minimal effect on extent of absorption; however, time to peak plasma concentration is delayed by about 40 minutes. Thalidomide: Thalidomide and other agents that slow cardiac conduction such as alpha-blockers should be used cautiously due to the potential for additive bradycardia. The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply. Terazosin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment. Serum potassium should be maintained within the normal range before Tikosyn treatment is initiated and should be maintained within the normal range while the patient remains on Tikosyn therapy. Sperzel WD, Glassman HN, Jordan DC, Luther RR "Overall safety of terazosin as an antihypertensive agent. There is no information on the presence of dofetilide in breast milk. Patients should be advised not to breast-feed an infant if they are taking Tikosyn. What types of laxatives are there? Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Tikosyn dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. This effect, and the related increase in effective refractory period, is observed in the atria and ventricles in both resting and paced electrophysiology studies. The increase in QT interval observed on the surface ECG is a result of prolongation of both effective and functional refractory periods in the His-Purkinje system and the ventricles. Blood pressure is the tension of the blood within the blood vessels. If blood is pumped too forcefully, or if the blood vessels are too narrow, the pressure of the blood against the walls of the vessels rises. armidex
The adverse events were usually transient and mild or moderate in intensity, but sometimes were serious enough to interrupt treatment. In the placebo-controlled clinical trials, the rates of premature termination due to adverse events were not statistically different between the placebo and Terazosin groups. Terazosin capsules relax the tightness of a certain type of muscle in the prostate and at the opening of the bladder. Administration of supplemental doses of the drug following hemodialysis does not appear to be necessary. PROTECT FROM MOISTURE AND HUMIDITY. Each increase should be delayed until BP has stabilized at a given dosage. Additional adverse events have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. The safety profile of patients treated in the long-term study was similar to that observed in the controlled studies. Acetaminophen; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. silagra
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If you take too much Tikosyn, call your doctor or go to the nearest hospital emergency room right away. Take your Tikosyn capsules with you to show to the doctor. Dobutamine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Achari R, Laddu A "Terazosin: a new alpha adrenoceptor blocking drug. Bruskewitz RC. Benign prostatic hyperplasia: drug and nondrug therapies. Geriatrics.
Oesterling JE. Benign prostatic hyperplasia: medical and minimally invasive treatment options. N Engl J Med. Should overdosage of Terazosin capsules lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, shock should first be treated with volume expanders. If necessary, vasopressors should then be used and renal function should be monitored and supported as needed. Laboratory data indicate that Terazosin capsules are 90-94% protein bound; therefore, dialysis may not be of benefit.
Babamoto KS, Hirokawa WT. Doxazosin: a new α 1-adrenergic antagonist. Clin Pharm. Tikosyn is indicated for the conversion of atrial fibrillation and atrial flutter to normal sinus rhythm. The drug is 90 to 94% bound to plasma proteins and binding is constant over the clinically observed concentration range. Approximately 10% of an orally administered dose is excreted as parent drug in the urine and approximately 20% is excreted in the feces. The remainder is eliminated as metabolites. Impaired renal function had no significant effect on the elimination of Terazosin, and dosage adjustment of Terazosin to compensate for the drug removal during hemodialysis approximately 10% does not appear to be necessary. Overall, approximately 40% of the administered dose is excreted in the urine and approximately 60% in the feces. The disposition of the compound in animals is qualitatively similar to that in man.
Candida in the vagina. The usual recommended dose of Tikosyn is 500 mcg BID, as modified by the dosing algorithm described below. For consideration of a lower dose, see below. Tikosyn and placebo for 551 and 207 patient years, respectively.